tag:blogger.com,1999:blog-7402247635006701650.post3387174116503633468..comments2023-06-30T00:57:26.573-07:00Comments on Leukemia Fighter! (CML); I Am Dancing and Traveling My Way Through: Disgusted CML Day!Michelehttp://www.blogger.com/profile/18185513255737012093noreply@blogger.comBlogger4125tag:blogger.com,1999:blog-7402247635006701650.post-32546891215554881082018-03-07T12:43:30.697-08:002018-03-07T12:43:30.697-08:00Lottie, there is no doubt about that! They are my ...Lottie, there is no doubt about that! They are my light!!Michelehttps://www.blogger.com/profile/18185513255737012093noreply@blogger.comtag:blogger.com,1999:blog-7402247635006701650.post-6157398797970190032018-03-07T12:01:43.123-08:002018-03-07T12:01:43.123-08:00I hope you feel well enough to enjoy the Grandkids...I hope you feel well enough to enjoy the Grandkids... I know mine have a way of brightening my days and busying me enough that I forget the worries for a while. LOTTIEFLAhttps://www.blogger.com/profile/17945254997397177541noreply@blogger.comtag:blogger.com,1999:blog-7402247635006701650.post-56162969648087177272018-03-07T10:02:48.664-08:002018-03-07T10:02:48.664-08:00Hi Kat,
Well, isn't that just special!? lol Wo...Hi Kat,<br />Well, isn't that just special!? lol Won't it just be my luck?? i am going for a chest xray today, so we shall see where I am at; I was off at TKI's for three weeks and then slowly introduced the bosulif. I was on 100mg's of Sprycel, 5 days a week at the end (after six and a half years) and my PCR was around .042, which I was thrilled with. My pulmonologist said the same thing about a "small" effusions, problem was, that normal became about a two liter effusion! And yes, I am in the "What it" this drug doesn't work mode....boo hiss!<br />Thanks for your input; it is much appreciated!Michelehttps://www.blogger.com/profile/18185513255737012093noreply@blogger.comtag:blogger.com,1999:blog-7402247635006701650.post-78006064406171291762018-03-07T09:16:18.555-08:002018-03-07T09:16:18.555-08:00Michele - There have been a couple of case studies...Michele - There have been a couple of case studies where Sprycel patients with pleural effusions continued to have them when switched to Bosulif. It may be because of the inhibition of Src kinases in both drugs. It's being studied currently. This is one of the reasons I didn't want to risk switching, but I may have to in the future and then I'll be back in your boat! Currently, my pulmonologist says I can walk around safely with a small amount of pleural fluid while taking 25 mg (half the 50's I have)of Sprycel. Latest PCR showed the 25 was keeping me at 0.02, which I hope will go back eventually to what I had before (my best) of <0.01. And, btw, from what I hear on the LLS and UK discussion forums, the Bosulif diarrhea typically doesn't kick in for a couple of weeks, then it does, and most (most) goes away after a couple of months. I don't know about the nausea. I sure remember that with Gleevec - taking it with food didn't always work. Nausea, all by itself, is depressing. When I don't feel good, all the stuff like hanging on hold on the phone and insurance hassles loom way too large. Not to mention the fear and worry over "what if I can't take THIS drug either? Then what?" Been there! (Am there.) I hope all this settles down for you and that you have a wonderful time with the grands.Kathttps://www.blogger.com/profile/11344636616546295258noreply@blogger.com